Assay Detail
Binding
CHEMBL4685386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ABCC1 transfected in MDCK2-MRP1 cells using calcein-AM as substrate measured after 1 hr by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK2-MRP1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.31 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011288 | — | — | 1 | 5.44 |
| CHEMBL488910 | — | — | 1 | 5.18 |
| CHEMBL4786467 | — | — | 1 | - |
| CHEMBL4748169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011288 | — | IC50 | = | 3599.0 | nM | 5.44 |
| CHEMBL488910 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL4786467 | — | IC50 | >= | 39750.0 | nM | - |
| CHEMBL4748169 | — | IC50 | >= | 19040.0 | nM | - |