Assay Detail
Binding
CHEMBL4685759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 8 mins in presence of ATP by colorimetric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comparative analysis of the dual EGFR-DNA targeting and growth inhibitory properties of 6-mono-alkylamino- and 6,6-dialkylaminoquinazoline-based type II combi-molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.93 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181617 | — | — | 1 | 8.00 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.51 |
| CHEMBL4765122 | — | — | 1 | 6.30 |
| CHEMBL4757104 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181617 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL939 | GEFITINIB | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4765122 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL4757104 | — | IC50 | = | 1257.0 | nM | 5.90 |