Assay Detail
Functional
CHEMBL4686306
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Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by trypan blue dye exclusion method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.20 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745937 | — | — | 1 | 9.19 |
| CHEMBL4755980 | — | — | 1 | 9.11 |
| CHEMBL4765146 | — | — | 1 | 8.77 |
| CHEMBL4764595 | — | — | 1 | 7.87 |
| CHEMBL4754982 | — | — | 1 | 7.84 |
| CHEMBL4790597 | — | — | 1 | 7.68 |
| CHEMBL4751666 | — | — | 1 | 7.63 |
| CHEMBL4740264 | — | — | 1 | 7.53 |
| CHEMBL4752607 | — | — | 1 | - |
| CHEMBL4743927 | — | — | 1 | - |
| CHEMBL4750974 | — | — | 1 | - |
| CHEMBL4763618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745937 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL4755980 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL4765146 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4764595 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL4754982 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL4790597 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4751666 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL4740264 | — | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL4752607 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4743927 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4750974 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4763618 | — | IC50 | > | 100.0 | nM | - |