Assay Detail
Functional
CHEMBL4686453
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel octapeptide-DTX prodrugs targeting MMP-7 as effective agents for the treatment of colorectal cancer with lower systemic toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.84 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499248 | — | — | 1 | 10.00 |
| CHEMBL4800124 | — | — | 1 | 8.55 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 8.46 |
| CHEMBL4777936 | — | — | 1 | 8.28 |
| CHEMBL4748310 | — | — | 1 | 8.27 |
| CHEMBL4796068 | — | — | 1 | 8.14 |
| CHEMBL4751149 | — | — | 1 | 8.04 |
| CHEMBL4756701 | — | — | 1 | 8.01 |
| CHEMBL4790975 | — | — | 1 | 7.95 |
| CHEMBL4762468 | — | — | 1 | 7.68 |
| CHEMBL4794037 | — | — | 1 | 7.59 |
| CHEMBL4784350 | — | — | 1 | 6.36 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499248 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4800124 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4777936 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4748310 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4796068 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4751149 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4756701 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4790975 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL4762468 | — | IC50 | = | 20.9 | nM | 7.68 |
| CHEMBL4794037 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL4784350 | — | IC50 | = | 439.4 | nM | 6.36 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 26042.5 | nM | 4.58 |