Assay Detail
ADMET
CHEMBL4686455
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel octapeptide-DTX prodrugs targeting MMP-7 as effective agents for the treatment of colorectal cancer with lower systemic toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.74 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499248 | — | — | 1 | 6.44 |
| CHEMBL4794037 | — | — | 1 | 5.21 |
| CHEMBL4796068 | — | — | 1 | 4.96 |
| CHEMBL4756701 | — | — | 1 | 4.82 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 4.71 |
| CHEMBL4762468 | — | — | 1 | 4.67 |
| CHEMBL4784350 | — | — | 1 | 4.42 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.10 |
| CHEMBL4800124 | — | — | 1 | 4.06 |
| CHEMBL4748310 | — | — | 1 | 4.03 |
| CHEMBL4777936 | — | — | 1 | - |
| CHEMBL4790975 | — | — | 1 | - |
| CHEMBL4751149 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499248 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4794037 | — | IC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL4796068 | — | IC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL4756701 | — | IC50 | = | 15240.0 | nM | 4.82 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL4762468 | — | IC50 | = | 21310.0 | nM | 4.67 |
| CHEMBL4784350 | — | IC50 | = | 38310.0 | nM | 4.42 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 79320.0 | nM | 4.10 |
| CHEMBL4800124 | — | IC50 | = | 86790.0 | nM | 4.06 |
| CHEMBL4748310 | — | IC50 | = | 94110.0 | nM | 4.03 |
| CHEMBL4777936 | — | IC50 | = | 165340.0 | nM | - |
| CHEMBL4790975 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL4751149 | — | IC50 | = | 136830.0 | nM | - |