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Assay Detail

CHEMBL4687754

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MDM2 (unknown origin) by cell-based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

E3 ubiquitin-protein ligase Mdm2 (CHEMBL5023)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon.
Talele TT
J Med Chem (2020) 63 : 13291 -13315
PubMed 32805118 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.00 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2381408 SAR-405838 1.0 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2381408 SAR-405838 IC50 = 100.0 nM 7.00