Assay Detail
Binding
CHEMBL4688199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum FLN
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Falcilysin (CHEMBL4295876) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum (isolate 3D7) |
Publication
Structure guided development of potent piperazine-derived hydroxamic acid inhibitors targeting falcilysin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.61 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4799253 | — | — | 1 | 6.66 |
| CHEMBL4743280 | — | — | 1 | 6.22 |
| CHEMBL4782486 | — | — | 1 | 6.05 |
| CHEMBL4799260 | — | — | 1 | 6.00 |
| CHEMBL4797916 | — | — | 1 | 5.96 |
| CHEMBL4794156 | — | — | 1 | 5.85 |
| CHEMBL4749474 | — | — | 1 | 5.85 |
| CHEMBL4785958 | — | — | 1 | 5.77 |
| CHEMBL4741390 | — | — | 1 | 5.60 |
| CHEMBL4753948 | — | — | 1 | 5.60 |
| CHEMBL4763576 | — | — | 1 | 5.58 |
| CHEMBL4225532 | — | — | 1 | 5.52 |
| CHEMBL4759772 | — | — | 1 | 5.46 |
| CHEMBL4787612 | — | — | 1 | 5.40 |
| CHEMBL4797275 | — | — | 1 | 5.40 |
| CHEMBL4749198 | — | — | 1 | 5.40 |
| CHEMBL4747594 | — | — | 1 | 5.40 |
| CHEMBL4746210 | — | — | 1 | 5.31 |
| CHEMBL4786923 | — | — | 1 | 5.30 |
| CHEMBL4744749 | — | — | 1 | 5.05 |
| CHEMBL4748768 | — | — | 1 | 5.00 |
| CHEMBL4760331 | — | — | 1 | 4.96 |
| CHEMBL4793336 | — | — | 1 | - |
| CHEMBL4743581 | — | — | 1 | - |
| CHEMBL4783383 | — | — | 1 | - |
| CHEMBL4779972 | — | — | 1 | - |
| CHEMBL4795927 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4799253 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL4743280 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL4782486 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL4799260 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4797916 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL4794156 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4749474 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4785958 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL4741390 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL4753948 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL4763576 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL4225532 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL4759772 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL4787612 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL4797275 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL4749198 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL4747594 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL4746210 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL4786923 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL4744749 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL4748768 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4760331 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL4793336 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL4743581 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL4783383 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL4779972 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL4795927 | — | Ki | > | 25000.0 | nM | - |