Assay Detail
Binding
CHEMBL4689514
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Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass spectrophotometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Oxazine Monoacylglycerol Lipase (MAGL) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 10.25 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749516 | — | — | 1 | 10.52 |
| CHEMBL4759880 | — | — | 1 | 10.40 |
| CHEMBL4785835 | — | — | 1 | 10.40 |
| CHEMBL4745872 | — | — | 1 | 10.15 |
| CHEMBL4756662 | — | — | 1 | 10.00 |
| CHEMBL4749293 | — | — | 1 | 10.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749516 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4759880 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4785835 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4745872 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL4756662 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4749293 | — | IC50 | = | 0.1 | nM | 10.00 |