Assay Detail
Binding
CHEMBL4699728
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization (unknown origin) incubated for 1 hr by fluorescence based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.23 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761168 | — | — | 1 | 6.77 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.72 |
| CHEMBL4280415 | — | — | 1 | 5.74 |
| CHEMBL4746357 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761168 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL107 | COLCHICINE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4280415 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL4746357 | — | IC50 | = | 2040.0 | nM | 5.69 |