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Assay Detail

CHEMBL4699741

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of tubulin polymerization (unknown origin) measured for every 1 min interval for 90 mins by fluorescence based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Tubulin (CHEMBL2095182)
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents
Malik, M. Shaheer, Ahmed, Saleh A., Althagafi, Ismail I., Ansari, Mohammed Azam, Kamal, Ahmed
RSC Med Chem (2020) 11 : 327 -348
PubMed 33479639 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.80 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4743390 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4743390 IC50 = 1600.0 nM 5.80