Assay Detail
Functional
CHEMBL4699783
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis and biological evaluation of sanguinarine derivatives as anti-non-small cell lung cancer agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.78 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4748987 | — | — | 1 | 6.02 |
| CHEMBL4762055 | — | — | 1 | 5.90 |
| CHEMBL4744594 | — | — | 1 | 5.84 |
| CHEMBL4799513 | — | — | 1 | 5.83 |
| CHEMBL4171637 | — | — | 1 | 5.80 |
| CHEMBL490129 | SANGUINARIUM CHLORIDE | 2.0 | 1 | 5.80 |
| CHEMBL4751602 | — | — | 1 | 5.75 |
| CHEMBL4778901 | — | — | 1 | 5.71 |
| CHEMBL4787245 | — | — | 1 | 5.36 |
| CHEMBL465678 | DIHYDROSANGUINARINE | — | 1 | - |
| CHEMBL4751586 | — | — | 1 | - |
| CHEMBL4764713 | — | — | 1 | - |
| CHEMBL4746623 | — | — | 1 | - |
| CHEMBL4764924 | — | — | 1 | - |
| CHEMBL4785846 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4748987 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4762055 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4744594 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4799513 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4171637 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL490129 | SANGUINARIUM CHLORIDE | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4751602 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4778901 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL4787245 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL465678 | DIHYDROSANGUINARINE | IC50 | > | 30000.0 | nM | - |
| CHEMBL4751586 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4764713 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4746623 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4764924 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4785846 | — | IC50 | > | 30000.0 | nM | - |