Compound Detail
CHEMBL465678
DIHYDROSANGUINARINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL465678 |
| Name | DIHYDROSANGUINARINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CIUHLXZTZWTVFL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
333.3
MW (Da)
3.91
ALogP
5
HBA
0
HBD
40.2
PSA (Ų)
0.62
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NCI-H1975 CHEMBL614348 | IC50 | 4.72 | 4.72 | 19140.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NCI-H1975 | IC50 | = | 19140.0 | nM | 4.72 | Antiproliferative activity against human H1975 cells assessed as inhibition of c... | 33479636 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1021/np50074a026 | Penicillium oxalicum | 1 |
| - | 10.1021/np50074a026 | Bacillus subtilis | 1 |
| - | 10.1021/np50074a026 | Micrococcus luteus | 1 |
| - | 10.1021/np50074a026 | Escherichia coli | 1 |
| 24794108 | 10.1016/j.bmcl.2014.04.047 | Aromatic-L-amino-acid decarboxylase | 1 |
| 29400966 | 10.1021/acs.jnatprod.7b00847 | Acetylcholinesterase | 1 |
| 28641156 | 10.1016/j.ejmech.2017.06.021 | Unchecked | 1 |
| 28641156 | 10.1016/j.ejmech.2017.06.021 | PC-3 | 1 |
| 28641156 | 10.1016/j.ejmech.2017.06.021 | HCT-15 | 1 |
| 28641156 | 10.1016/j.ejmech.2017.06.021 | MCF7 | 1 |
| 33479636 | 10.1039/c9md00494g | A549 | 1 |
| 33479636 | 10.1039/c9md00494g | NCI-H1975 | 1 |
Data from ChEMBL 36 via Core Engine