Assay Detail
Functional
CHEMBL4700085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 infected in human HEK293 cells assessed as parasite growth inhibition measured after 48 hrs by alamar blue assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 5.54 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.85 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 7.42 |
| CHEMBL380216 | DIMINAZENE DIACETURATE | — | 1 | 7.06 |
| CHEMBL4758264 | — | — | 1 | 6.05 |
| CHEMBL4743083 | — | — | 1 | 5.82 |
| CHEMBL3431111 | — | — | 1 | 5.70 |
| CHEMBL4747355 | — | — | 1 | 5.70 |
| CHEMBL4796000 | — | — | 1 | 5.68 |
| CHEMBL4785216 | — | — | 1 | 5.64 |
| CHEMBL4800536 | — | — | 1 | 5.62 |
| CHEMBL4777875 | — | — | 1 | 5.62 |
| CHEMBL4784548 | — | — | 1 | 5.60 |
| CHEMBL4778729 | — | — | 1 | 5.58 |
| CHEMBL4746059 | — | — | 1 | 5.58 |
| CHEMBL4777056 | — | — | 1 | 5.55 |
| CHEMBL4787692 | — | — | 1 | 5.54 |
| CHEMBL2098075 | — | — | 1 | 5.51 |
| CHEMBL4781677 | — | — | 1 | 5.50 |
| CHEMBL4748426 | — | — | 1 | 5.50 |
| CHEMBL4756128 | — | — | 1 | 5.47 |
| CHEMBL4743470 | — | — | 1 | 5.46 |
| CHEMBL4746266 | — | — | 1 | 5.44 |
| CHEMBL4746844 | — | — | 1 | 5.44 |
| CHEMBL4777653 | — | — | 1 | 5.44 |
| CHEMBL4760278 | — | — | 1 | 5.43 |
| CHEMBL3235190 | — | — | 1 | 5.42 |
| CHEMBL1443198 | — | — | 1 | 5.42 |
| CHEMBL4791657 | — | — | 1 | 5.39 |
| CHEMBL4795724 | — | — | 1 | 5.37 |
| CHEMBL4795131 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL380216 | DIMINAZENE DIACETURATE | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4758264 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4743083 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3431111 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4747355 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4796000 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4785216 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4800536 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4777875 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4784548 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4746059 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4778729 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4777056 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4787692 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2098075 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4781677 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4748426 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4756128 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4743470 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4746266 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4746844 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4777653 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4760278 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1443198 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3235190 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4791657 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4795724 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4795131 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4750809 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4747847 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4749436 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4751320 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4790719 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4740748 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4740712 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4782335 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4786189 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4751949 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4757252 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4749669 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4744411 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4751511 | — | IC50 | > | 83000.0 | nM | - |
| CHEMBL4790847 | — | IC50 | > | 83000.0 | nM | - |
| CHEMBL4778352 | — | IC50 | > | 83000.0 | nM | - |
| CHEMBL4788748 | — | IC50 | > | 83000.0 | nM | - |
| CHEMBL4792087 | — | IC50 | > | 83000.0 | nM | - |
| CHEMBL4743974 | — | IC50 | > | 83000.0 | nM | - |