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Assay Detail

CHEMBL4700293

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Vaccinia virus Copenhagen infected in African green monkey Vero cells assessed as reduction in cell survival incubated for 4 days by neutral red dye based colorimetric analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Vaccinia virus
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

Vaccinia virus (CHEMBL613493)
Type ORGANISM
Organism Vaccinia virus

Publication

New chemical agents based on adamantane-monoterpene conjugates against orthopoxvirus infections
Suslov, Evgenii V., Mozhaytsev, Evgenii S., Korchagina, Dina V., Bormotov, Nikolay I., Yarovaya, Olga I., Volcho, Konstantin P., Serova, Olga A., Agafonov, Alexander P., Maksyutov, Rinat A., Shishkina, Larisa N., Salakhutdinov, Nariman F.
RSC Med Chem (2020) 11 : 1185 -1195
PubMed 33479623 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.54 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL485653 1 8.00
CHEMBL4761483 1 6.22
CHEMBL4794434 1 6.16
CHEMBL4789170 1 5.77
CHEMBL4759505 1 5.75
CHEMBL4798123 1 5.64
CHEMBL4752293 1 5.60
CHEMBL4777797 1 5.60
CHEMBL4745723 1 5.58
CHEMBL4764761 1 5.55
CHEMBL4755507 1 5.51
CHEMBL4752180 1 5.44
CHEMBL4758977 1 5.36
CHEMBL4748821 1 5.34
CHEMBL4753749 1 5.23
CHEMBL4762951 1 4.97
CHEMBL4740429 1 4.91
CHEMBL4741759 1 4.84
CHEMBL4750107 1 4.83
CHEMBL5314375 CIDOFOVIR 4.0 1 4.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL485653 IC50 = 10.0 nM 8.00
CHEMBL4761483 IC50 = 600.0 nM 6.22
CHEMBL4794434 IC50 = 700.0 nM 6.16
CHEMBL4789170 IC50 = 1700.0 nM 5.77
CHEMBL4759505 IC50 = 1800.0 nM 5.75
CHEMBL4798123 IC50 = 2300.0 nM 5.64
CHEMBL4752293 IC50 = 2500.0 nM 5.60
CHEMBL4777797 IC50 = 2500.0 nM 5.60
CHEMBL4745723 IC50 = 2600.0 nM 5.58
CHEMBL4764761 IC50 = 2800.0 nM 5.55
CHEMBL4755507 IC50 = 3100.0 nM 5.51
CHEMBL4752180 IC50 = 3600.0 nM 5.44
CHEMBL4758977 IC50 = 4400.0 nM 5.36
CHEMBL4748821 IC50 = 4600.0 nM 5.34
CHEMBL4753749 IC50 = 5900.0 nM 5.23
CHEMBL4762951 IC50 = 10600.0 nM 4.97
CHEMBL4740429 IC50 = 12300.0 nM 4.91
CHEMBL4741759 IC50 = 14400.0 nM 4.84
CHEMBL4750107 IC50 = 14800.0 nM 4.83
CHEMBL5314375 CIDOFOVIR IC50 = 40000.0 nM 4.40