Assay Detail
Binding
CHEMBL4700550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.62 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.68 |
| CHEMBL193482 | ESTRIOL | 4.0 | 1 | 4.70 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 4.22 |
| CHEMBL274826 | ANDROSTENEDIONE | -1.0 | 1 | 4.07 |
| CHEMBL1405 | ESTRONE | 4.0 | 1 | 4.03 |
| CHEMBL386630 | TESTOSTERONE | 4.0 | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL193482 | ESTRIOL | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL274826 | ANDROSTENEDIONE | IC50 | = | 85900.0 | nM | 4.07 |
| CHEMBL1405 | ESTRONE | IC50 | = | 93100.0 | nM | 4.03 |
| CHEMBL386630 | TESTOSTERONE | IC50 | = | 96800.0 | nM | 4.01 |