Assay Detail
Binding
CHEMBL4700552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.23 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81379 | RETINAL | — | 1 | 6.72 |
| CHEMBL986 | RETINOL | 4.0 | 1 | 6.72 |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | 6.68 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 6.66 |
| CHEMBL164 | MYRICETIN | — | 1 | 6.66 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.66 |
| CHEMBL4787961 | — | — | 1 | 6.60 |
| CHEMBL32749 | FERULATE | -1.0 | 1 | 6.12 |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | 6.10 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 5.52 |
| CHEMBL1440 | TETRACYCLINE | 4.0 | 1 | 5.22 |
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81379 | RETINAL | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL986 | RETINOL | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL324842 | ROSMARINIC ACID | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL140 | CURCUMIN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL164 | MYRICETIN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4787961 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL32749 | FERULATE | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL583912 | (-)-EPICATECHIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL38 | TRETINOIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1440 | TETRACYCLINE | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL374478 | RIFAMPIN | IC50 | = | 7100.0 | nM | 5.15 |