Assay Detail
Binding
CHEMBL4700554
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Inhibition of wild type alpha-synuclein aggregation (unknown origin) expressed in Escherichia coli BL21 cells incubated for 30 days by thioflavin T based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.55 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761445 | — | — | 1 | 5.04 |
| CHEMBL258632 | — | — | 1 | 4.05 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761445 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL258632 | — | IC50 | = | 89100.0 | nM | 4.05 |
| CHEMBL140 | CURCUMIN | IC50 | = | 161800.0 | nM | - |
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | = | 126800.0 | nM | - |