Assay Detail
Binding
CHEMBL4700565
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Inhibition of wild type human alpha-synuclein fibrillization expressed in Escherichia coli BL21(DE3)pLysS by thioflavin-T based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.82 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1550 | PHYTONADIONE | 4.0 | 1 | 4.82 |
| CHEMBL259223 | MENATETRENONE | 3.0 | 1 | 4.82 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 4.82 |
| CHEMBL55934 | NAPHTHOQUINONE | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1550 | PHYTONADIONE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL259223 | MENATETRENONE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL590 | MENADIONE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL55934 | NAPHTHOQUINONE | IC50 | = | 15000.0 | nM | 4.82 |