Assay Detail
Binding
CHEMBL4700570
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Inhibition of amyloid beta (1 to 40) (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.75 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81379 | RETINAL | — | 1 | 6.75 |
| CHEMBL986 | RETINOL | 4.0 | 1 | 6.75 |
| CHEMBL4787961 | — | — | 1 | 6.75 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81379 | RETINAL | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL986 | RETINOL | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4787961 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL38 | TRETINOIN | IC50 | = | 180.0 | nM | 6.75 |