Assay Detail
Functional
CHEMBL4700874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-361 cells assessed as growth inhibition after 48 hrs by PrestoBlue dye based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-361 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Position of lipidation influences anticancer activity of Smac analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.38 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753399 | — | — | 1 | 6.58 |
| CHEMBL4749062 | — | — | 1 | 5.77 |
| CHEMBL3623511 | — | — | 1 | 5.51 |
| CHEMBL4755167 | — | — | 1 | 5.17 |
| CHEMBL4757749 | — | — | 1 | 5.05 |
| CHEMBL4782637 | — | — | 1 | 5.00 |
| CHEMBL4751547 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4753399 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4749062 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3623511 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4755167 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4757749 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4782637 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4751547 | — | EC50 | = | 25000.0 | nM | 4.60 |