Assay Detail
Binding
CHEMBL4700997
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Antagonist activity at human adenosine 2A receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Adenosine A Receptor Antagonists for Cancer Immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.53 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113142 | ZM-241385 | — | 1 | 9.10 |
| CHEMBL17127 | SCH-58261 | — | 1 | 8.96 |
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | 7.44 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113142 | ZM-241385 | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL17127 | SCH-58261 | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL431770 | ISTRADEFYLLINE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL113 | CAFFEINE | Ki | = | 23400.0 | nM | 4.63 |