Assay Detail
Binding
CHEMBL4701116
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BTK in human PBMC assessed as reduction in anti-IgD-induced B cell activation preincubated for 30 mins followed by rabbit F(ab')2 anti-human IgD stimulation and measured after 18 to 22 hrs by CD19-APC and CD69-PE staining based flow cytometry
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.96 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744041 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744041 | — | IC50 | = | 110.0 | nM | 6.96 |