Assay Detail
Functional
CHEMBL4701481
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Cytotoxicity against mouse L5178Y cells assessed as reduction in cell viability by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L5178Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H receptor and cancer resistance proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.62 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4171151 | — | — | 1 | 8.04 |
| CHEMBL4170350 | — | — | 1 | 7.93 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 7.90 |
| CHEMBL4170784 | — | — | 1 | 7.90 |
| CHEMBL4163913 | — | — | 1 | 7.82 |
| CHEMBL4159046 | — | — | 1 | 7.74 |
| CHEMBL4166945 | — | — | 1 | 7.68 |
| CHEMBL4166262 | — | — | 1 | 7.39 |
| CHEMBL4162840 | — | — | 1 | 7.33 |
| CHEMBL4445569 | — | — | 1 | 7.32 |
| CHEMBL4452580 | — | — | 1 | 7.20 |
| CHEMBL4473431 | — | — | 1 | 7.16 |
| CHEMBL4547780 | — | — | 1 | - |
| CHEMBL4519189 | — | — | 1 | - |
| CHEMBL4467220 | — | — | 1 | - |
| CHEMBL4453108 | — | — | 1 | - |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4171151 | — | IC50 | = | 9.23 | nM | 8.04 |
| CHEMBL4170350 | — | IC50 | = | 11.67 | nM | 7.93 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 12.72 | nM | 7.90 |
| CHEMBL4170784 | — | IC50 | = | 12.56 | nM | 7.90 |
| CHEMBL4163913 | — | IC50 | = | 15.08 | nM | 7.82 |
| CHEMBL4159046 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL4166945 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL4166262 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL4162840 | — | IC50 | = | 46.4 | nM | 7.33 |
| CHEMBL4445569 | — | IC50 | = | 47.5 | nM | 7.32 |
| CHEMBL4452580 | — | IC50 | = | 63.72 | nM | 7.20 |
| CHEMBL4473431 | — | IC50 | = | 68.99 | nM | 7.16 |
| CHEMBL4547780 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4519189 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4467220 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4453108 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL6966 | VERAPAMIL | IC50 | > | 100.0 | nM | - |