Assay Detail
Functional
CHEMBL4701482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against multidrug resistance mouse L5178Y cells expressing human MDR1 assessed as reduction in cell viability by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L5178Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H receptor and cancer resistance proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.56 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 8.13 |
| CHEMBL4171151 | — | — | 1 | 8.12 |
| CHEMBL4170350 | — | — | 1 | 7.98 |
| CHEMBL4170784 | — | — | 1 | 7.89 |
| CHEMBL4163913 | — | — | 1 | 7.78 |
| CHEMBL4166945 | — | — | 1 | 7.75 |
| CHEMBL4159046 | — | — | 1 | 7.56 |
| CHEMBL4162840 | — | — | 1 | 7.49 |
| CHEMBL4473431 | — | — | 1 | 7.36 |
| CHEMBL4452580 | — | — | 1 | 7.33 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 7.32 |
| CHEMBL4166262 | — | — | 1 | 7.31 |
| CHEMBL4581913 | — | — | 1 | 7.30 |
| CHEMBL4453108 | — | — | 1 | 7.26 |
| CHEMBL4445569 | — | — | 1 | 7.22 |
| CHEMBL4467220 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479 | THIORIDAZINE | IC50 | = | 7.43 | nM | 8.13 |
| CHEMBL4171151 | — | IC50 | = | 7.59 | nM | 8.12 |
| CHEMBL4170350 | — | IC50 | = | 10.49 | nM | 7.98 |
| CHEMBL4170784 | — | IC50 | = | 12.79 | nM | 7.89 |
| CHEMBL4163913 | — | IC50 | = | 16.68 | nM | 7.78 |
| CHEMBL4166945 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL4159046 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL4162840 | — | IC50 | = | 32.1 | nM | 7.49 |
| CHEMBL4473431 | — | IC50 | = | 43.99 | nM | 7.36 |
| CHEMBL4452580 | — | IC50 | = | 46.23 | nM | 7.33 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 47.85 | nM | 7.32 |
| CHEMBL4166262 | — | IC50 | = | 49.4 | nM | 7.31 |
| CHEMBL4581913 | — | IC50 | = | 49.7 | nM | 7.30 |
| CHEMBL4453108 | — | IC50 | = | 54.6 | nM | 7.26 |
| CHEMBL4445569 | — | IC50 | = | 60.3 | nM | 7.22 |
| CHEMBL4467220 | — | IC50 | = | 63.86 | nM | 7.20 |