Assay Detail
Binding
CHEMBL4701487
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Inhibition of SYK (unknown origin)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 9.12 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4758052 | — | — | 1 | 9.72 |
| CHEMBL4740533 | — | — | 1 | 9.70 |
| CHEMBL4740065 | — | — | 1 | 9.68 |
| CHEMBL4797815 | — | — | 1 | 9.66 |
| CHEMBL4785413 | — | — | 1 | 9.64 |
| CHEMBL4800498 | — | — | 1 | 9.62 |
| CHEMBL4776734 | — | — | 1 | 9.52 |
| CHEMBL4751083 | — | — | 1 | 9.51 |
| CHEMBL4786007 | — | — | 1 | 9.48 |
| CHEMBL4742918 | — | — | 1 | 9.47 |
| CHEMBL4748041 | — | — | 1 | 9.47 |
| CHEMBL4763433 | — | — | 1 | 9.44 |
| CHEMBL4795975 | — | — | 1 | 9.40 |
| CHEMBL4782062 | — | — | 1 | 9.29 |
| CHEMBL4753097 | — | — | 1 | 9.22 |
| CHEMBL4760325 | — | — | 1 | 9.14 |
| CHEMBL4796370 | — | — | 1 | 9.08 |
| CHEMBL4741509 | — | — | 1 | 9.06 |
| CHEMBL4758301 | — | — | 1 | 8.89 |
| CHEMBL4743842 | — | — | 1 | 8.82 |
| CHEMBL4760470 | — | — | 1 | 8.54 |
| CHEMBL4741959 | — | — | 1 | 8.49 |
| CHEMBL4787606 | — | — | 1 | 8.10 |
| CHEMBL4781915 | — | — | 1 | 7.96 |
| CHEMBL4786769 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4758052 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4740533 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4740065 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL4797815 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL4785413 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL4800498 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL4776734 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4751083 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL4786007 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL4742918 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL4748041 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL4763433 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL4795975 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4782062 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL4753097 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4760325 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL4796370 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL4741509 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL4758301 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4743842 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4760470 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4741959 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4787606 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4781915 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4786769 | — | IC50 | = | 62.0 | nM | 7.21 |