Assay Detail
Binding
CHEMBL4701738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT3 ITD mutant (unknown origin) expressed in mouse BaF3 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of small molecule FLT3 inhibitors that are able to overcome drug-resistant mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.21 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744130 | — | — | 1 | 10.82 |
| CHEMBL4519741 | — | — | 1 | 10.42 |
| CHEMBL4790915 | — | — | 1 | 10.14 |
| CHEMBL4749639 | — | — | 1 | 9.54 |
| CHEMBL4761091 | — | — | 1 | 8.92 |
| CHEMBL4781811 | — | — | 1 | 8.82 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 8.52 |
| CHEMBL4763034 | — | — | 1 | 8.51 |
| CHEMBL4765203 | — | — | 1 | 8.49 |
| CHEMBL4763828 | — | — | 1 | 8.32 |
| CHEMBL4791482 | — | — | 1 | 8.31 |
| CHEMBL4750430 | — | — | 1 | 8.29 |
| CHEMBL4795857 | — | — | 1 | 8.28 |
| CHEMBL4749484 | — | — | 1 | 8.24 |
| CHEMBL4782974 | — | — | 1 | 8.16 |
| CHEMBL4765096 | — | — | 1 | 8.14 |
| CHEMBL4780418 | — | — | 1 | 7.72 |
| CHEMBL4757207 | — | — | 1 | 7.44 |
| CHEMBL4755159 | — | — | 1 | 7.43 |
| CHEMBL4798245 | — | — | 1 | 7.18 |
| CHEMBL4793076 | — | — | 1 | 7.12 |
| CHEMBL4749438 | — | — | 1 | 6.85 |
| CHEMBL4744221 | — | — | 1 | 5.90 |
| CHEMBL4800630 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744130 | — | IC50 | = | 0.015 | nM | 10.82 |
| CHEMBL4519741 | — | IC50 | = | 0.038 | nM | 10.42 |
| CHEMBL4790915 | — | IC50 | = | 0.072 | nM | 10.14 |
| CHEMBL4749639 | — | IC50 | = | 0.292 | nM | 9.54 |
| CHEMBL4761091 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4781811 | — | IC50 | = | 1.51 | nM | 8.82 |
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 3.01 | nM | 8.52 |
| CHEMBL4763034 | — | IC50 | = | 3.08 | nM | 8.51 |
| CHEMBL4765203 | — | IC50 | = | 3.22 | nM | 8.49 |
| CHEMBL4763828 | — | IC50 | = | 4.73 | nM | 8.32 |
| CHEMBL4791482 | — | IC50 | = | 4.91 | nM | 8.31 |
| CHEMBL4750430 | — | IC50 | = | 5.17 | nM | 8.29 |
| CHEMBL4795857 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4749484 | — | IC50 | = | 5.77 | nM | 8.24 |
| CHEMBL4782974 | — | IC50 | = | 6.88 | nM | 8.16 |
| CHEMBL4765096 | — | IC50 | = | 7.25 | nM | 8.14 |
| CHEMBL4780418 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL4757207 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL4755159 | — | IC50 | = | 37.2 | nM | 7.43 |
| CHEMBL4798245 | — | IC50 | = | 66.5 | nM | 7.18 |
| CHEMBL4793076 | — | IC50 | = | 76.1 | nM | 7.12 |
| CHEMBL4749438 | — | IC50 | = | 140.9 | nM | 6.85 |
| CHEMBL4744221 | — | IC50 | = | 1258.0 | nM | 5.90 |
| CHEMBL4800630 | — | IC50 | = | 2649.0 | nM | 5.58 |