Compound Detail
CHEMBL4780418
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Basic Information
| ChEMBL ID | CHEMBL4780418 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ANCAHHAAUGCRLS-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
508.6
MW (Da)
6.89
ALogP
7
HBA
2
HBD
107.7
PSA (Ų)
0.27
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 7.83 | 7.6033 | 14.9 | 3 |
| BaF3 CHEMBL614524 | IC50 | 5.31 | 5.31 | 4935.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 14.9 | nM | 7.83 | Inhibition of FLT3 ITD/D835Y double mutant (unknown origin) expressed in mouse B... | 32891702 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 19.2 | nM | 7.72 | Inhibition of FLT3 ITD mutant (unknown origin) expressed in mouse BaF3 cells | 32891702 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 54.3 | nM | 7.26 | Inhibition of FLT3 ITD/F691L double mutant (unknown origin) expressed in mouse B... | 32891702 |
| BaF3 | IC50 | = | 4935.0 | nM | 5.31 | Cytotoxicity against mouse BaF3 cells assessed as reduction in cell viability | 32891702 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32891702 | 10.1016/j.bmcl.2020.127532 | Receptor-type tyrosine-protein kinase FLT3 | 3 |
| 32891702 | 10.1016/j.bmcl.2020.127532 | BaF3 | 1 |
Data from ChEMBL 36 via Core Engine