Assay Detail
Binding
CHEMBL4701739
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT3 ITD/D835Y double mutant (unknown origin) expressed in mouse BaF3 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of small molecule FLT3 inhibitors that are able to overcome drug-resistant mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.52 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790915 | — | — | 1 | 8.46 |
| CHEMBL4765203 | — | — | 1 | 8.29 |
| CHEMBL4763828 | — | — | 1 | 8.27 |
| CHEMBL4795857 | — | — | 1 | 8.22 |
| CHEMBL4749484 | — | — | 1 | 8.20 |
| CHEMBL4781811 | — | — | 1 | 8.10 |
| CHEMBL4791482 | — | — | 1 | 8.00 |
| CHEMBL4782974 | — | — | 1 | 7.97 |
| CHEMBL4750430 | — | — | 1 | 7.96 |
| CHEMBL4765096 | — | — | 1 | 7.96 |
| CHEMBL4744130 | — | — | 1 | 7.91 |
| CHEMBL4780418 | — | — | 1 | 7.83 |
| CHEMBL4763034 | — | — | 1 | 7.81 |
| CHEMBL4755159 | — | — | 1 | 7.55 |
| CHEMBL4749639 | — | — | 1 | 7.46 |
| CHEMBL4757207 | — | — | 1 | 7.21 |
| CHEMBL4761091 | — | — | 1 | 7.19 |
| CHEMBL4798245 | — | — | 1 | 6.98 |
| CHEMBL4519741 | — | — | 1 | 6.89 |
| CHEMBL4793076 | — | — | 1 | 6.80 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 6.28 |
| CHEMBL4749438 | — | — | 1 | 6.13 |
| CHEMBL4800630 | — | — | 1 | 5.45 |
| CHEMBL4744221 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790915 | — | IC50 | = | 3.48 | nM | 8.46 |
| CHEMBL4765203 | — | IC50 | = | 5.09 | nM | 8.29 |
| CHEMBL4763828 | — | IC50 | = | 5.35 | nM | 8.27 |
| CHEMBL4795857 | — | IC50 | = | 5.96 | nM | 8.22 |
| CHEMBL4749484 | — | IC50 | = | 6.28 | nM | 8.20 |
| CHEMBL4781811 | — | IC50 | = | 7.93 | nM | 8.10 |
| CHEMBL4791482 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL4782974 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL4750430 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4765096 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL4744130 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL4780418 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL4763034 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL4755159 | — | IC50 | = | 27.9 | nM | 7.55 |
| CHEMBL4749639 | — | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL4757207 | — | IC50 | = | 62.4 | nM | 7.21 |
| CHEMBL4761091 | — | IC50 | = | 64.2 | nM | 7.19 |
| CHEMBL4798245 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4519741 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4793076 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4749438 | — | IC50 | = | 741.1 | nM | 6.13 |
| CHEMBL4800630 | — | IC50 | = | 3540.8 | nM | 5.45 |
| CHEMBL4744221 | — | IC50 | > | 10000.0 | nM | - |