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Assay Detail

CHEMBL4701741

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ADMET
Cytotoxicity against mouse BaF3 cells assessed as reduction in cell viability
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type BaF3
Confidence 1 — Organism
Curated By Autocuration

Target

BaF3 (CHEMBL614524)
Type CELL-LINE
Organism Mus musculus

Publication

Discovery of small molecule FLT3 inhibitors that are able to overcome drug-resistant mutations.
Zhang G,Zhang W,Shen C,Nan J,Chen M,Lai S,Zhong J,Li B,Wang T,Wang Y,Yang S,Li L
Bioorg Med Chem Lett (2020) 30 : 127532 -127532
PubMed 32891702 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.52 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4765203 1 5.96
CHEMBL4763828 1 5.95
CHEMBL4790915 1 5.92
CHEMBL4795857 1 5.78
CHEMBL4749484 1 5.74
CHEMBL4750430 1 5.70
CHEMBL4782974 1 5.69
CHEMBL4744130 1 5.68
CHEMBL4749639 1 5.58
CHEMBL4765096 1 5.54
CHEMBL4761091 1 5.52
CHEMBL4791482 1 5.52
CHEMBL4519741 1 5.50
CHEMBL4763034 1 5.50
CHEMBL4757207 1 5.32
CHEMBL4780418 1 5.31
CHEMBL4798245 1 5.25
CHEMBL4755159 1 5.19
CHEMBL4793076 1 5.11
CHEMBL4800630 1 5.04
CHEMBL576982 QUIZARTINIB 4.0 1 5.03
CHEMBL4781811 1 -
CHEMBL4744221 1 -
CHEMBL4749438 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4765203 IC50 = 1097.1 nM 5.96
CHEMBL4763828 IC50 = 1125.2 nM 5.95
CHEMBL4790915 IC50 = 1212.4 nM 5.92
CHEMBL4795857 IC50 = 1645.6 nM 5.78
CHEMBL4749484 IC50 = 1840.0 nM 5.74
CHEMBL4750430 IC50 = 1996.3 nM 5.70
CHEMBL4782974 IC50 = 2034.8 nM 5.69
CHEMBL4744130 IC50 = 2084.0 nM 5.68
CHEMBL4749639 IC50 = 2623.2 nM 5.58
CHEMBL4765096 IC50 = 2877.7 nM 5.54
CHEMBL4761091 IC50 = 3035.4 nM 5.52
CHEMBL4791482 IC50 = 3000.2 nM 5.52
CHEMBL4519741 IC50 = 3156.3 nM 5.50
CHEMBL4763034 IC50 = 3137.5 nM 5.50
CHEMBL4757207 IC50 = 4817.0 nM 5.32
CHEMBL4780418 IC50 = 4935.0 nM 5.31
CHEMBL4798245 IC50 = 5556.1 nM 5.25
CHEMBL4755159 IC50 = 6500.1 nM 5.19
CHEMBL4793076 IC50 = 7774.1 nM 5.11
CHEMBL4800630 IC50 = 9203.9 nM 5.04
CHEMBL576982 QUIZARTINIB IC50 = 9312.2 nM 5.03
CHEMBL4781811 IC50 > 1988.1 nM -
CHEMBL4744221 IC50 > 10000.0 nM -
CHEMBL4749438 IC50 > 10000.0 nM -