Assay Detail
Functional
CHEMBL4701950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasodilating activity in Sprague-Dawley rat aortic rings assessed as reduction in phenylephrine-induced contractions
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Pyrazolo[3,4-b] Pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.79 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107834 | RIOCIGUAT | 4.0 | 1 | 6.75 |
| CHEMBL4785559 | — | — | 1 | 6.54 |
| CHEMBL4743189 | — | — | 1 | 6.44 |
| CHEMBL4792492 | — | — | 1 | 6.10 |
| CHEMBL4795950 | — | — | 1 | 6.03 |
| CHEMBL4797223 | — | — | 1 | 6.02 |
| CHEMBL4752923 | — | — | 1 | 6.00 |
| CHEMBL4782618 | — | — | 1 | 5.96 |
| CHEMBL4780823 | — | — | 1 | 5.80 |
| CHEMBL4783763 | — | — | 1 | 5.66 |
| CHEMBL4761659 | — | — | 1 | 5.31 |
| CHEMBL4761150 | — | — | 1 | 5.24 |
| CHEMBL4763850 | — | — | 1 | 5.09 |
| CHEMBL4752719 | — | — | 1 | 4.97 |
| CHEMBL4784189 | — | — | 1 | 4.90 |
| CHEMBL4749361 | — | — | 1 | - |
| CHEMBL4754851 | — | — | 1 | - |
| CHEMBL4782536 | — | — | 1 | - |
| CHEMBL4795558 | — | — | 1 | - |
| CHEMBL4749124 | — | — | 1 | - |
| CHEMBL4764302 | — | — | 1 | - |
| CHEMBL4745236 | — | — | 1 | - |
| CHEMBL478629 | DORSOMORPHIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107834 | RIOCIGUAT | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4785559 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4743189 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4792492 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4795950 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4797223 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4752923 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4782618 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4780823 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4783763 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4761659 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4761150 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4763850 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4752719 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4784189 | — | EC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4749361 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4754851 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4782536 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4795558 | — | EC50 | - | — | - | |
| CHEMBL4749124 | — | EC50 | - | — | - | |
| CHEMBL4764302 | — | EC50 | - | — | - | |
| CHEMBL4745236 | — | EC50 | - | — | - | |
| CHEMBL478629 | DORSOMORPHIN | EC50 | - | — | - |