Assay Detail
Functional
CHEMBL4703074
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Antiproliferative activity against human MOLM-13 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.78 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744558 | — | — | 1 | 8.05 |
| CHEMBL4759615 | — | — | 1 | 7.64 |
| CHEMBL4797708 | — | — | 1 | 7.48 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 7.22 |
| CHEMBL4760819 | — | — | 1 | 6.89 |
| CHEMBL4762268 | — | — | 1 | 6.52 |
| CHEMBL4758872 | — | — | 1 | 6.39 |
| CHEMBL4793693 | — | — | 1 | 6.19 |
| CHEMBL4799525 | — | — | 1 | 6.16 |
| CHEMBL4759152 | — | — | 1 | 5.29 |
| CHEMBL4748668 | — | — | 1 | - |
| CHEMBL4785347 | — | — | 1 | - |
| CHEMBL4788745 | — | — | 1 | - |
| CHEMBL4763950 | — | — | 1 | - |
| CHEMBL4743387 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744558 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4759615 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4797708 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL38434 | BREQUINAR | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4760819 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4762268 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4758872 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL4793693 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4799525 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4759152 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4748668 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4785347 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4788745 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4763950 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4743387 | — | IC50 | > | 3000.0 | nM | - |