Assay Detail
Binding
CHEMBL4703097
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Inhibition of PMA-induced MPO in human Neutrophil incubated for 3 mins by luminometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.63 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747269 | — | — | 1 | 4.89 |
| CHEMBL4753981 | — | — | 1 | 4.62 |
| CHEMBL4790231 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747269 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4753981 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4790231 | — | IC50 | = | 42000.0 | nM | 4.38 |