Assay Detail
Binding
CHEMBL4703099
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Inhibition of recombinant human MPO incubated for 10 mins in presence of 240 mM NaCl and 10 uM H2O2 by aminophenyl fluorescein based assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.94 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776850 | — | — | 1 | 7.80 |
| CHEMBL4780886 | — | — | 1 | 7.77 |
| CHEMBL4753981 | — | — | 1 | 7.60 |
| CHEMBL4764237 | — | — | 1 | 7.54 |
| CHEMBL4798810 | — | — | 1 | 7.50 |
| CHEMBL4530093 | — | — | 1 | 7.30 |
| CHEMBL4754467 | — | — | 1 | 7.24 |
| CHEMBL333928 | — | — | 1 | 6.98 |
| CHEMBL4762281 | — | — | 1 | 6.96 |
| CHEMBL4742088 | — | — | 1 | 6.90 |
| CHEMBL4788921 | — | — | 1 | 6.54 |
| CHEMBL4742000 | — | — | 1 | 6.17 |
| CHEMBL4760627 | — | — | 1 | 5.77 |
| CHEMBL4787700 | — | — | 1 | 5.13 |
| CHEMBL4740815 | — | — | 1 | - |
| CHEMBL4793857 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776850 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4780886 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4753981 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4764237 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4798810 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4530093 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4754467 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL333928 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4762281 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4742088 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4788921 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL4742000 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL4760627 | — | IC50 | = | 1696.0 | nM | 5.77 |
| CHEMBL4787700 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL4740815 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4793857 | — | IC50 | > | 40000.0 | nM | - |