Assay Detail
Binding
CHEMBL4703100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MPO incubated for 10 mins by amplex red dye based assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.72 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764237 | — | — | 1 | 7.77 |
| CHEMBL4780886 | — | — | 1 | 7.58 |
| CHEMBL4776850 | — | — | 1 | 7.50 |
| CHEMBL4530093 | — | — | 1 | 7.44 |
| CHEMBL4753981 | — | — | 1 | 7.37 |
| CHEMBL4798810 | — | — | 1 | 7.34 |
| CHEMBL4742088 | — | — | 1 | 7.11 |
| CHEMBL333928 | — | — | 1 | 6.99 |
| CHEMBL4754467 | — | — | 1 | 6.73 |
| CHEMBL4762281 | — | — | 1 | 6.37 |
| CHEMBL4788921 | — | — | 1 | 6.00 |
| CHEMBL4742000 | — | — | 1 | 5.85 |
| CHEMBL4760627 | — | — | 1 | 5.03 |
| CHEMBL4787700 | — | — | 1 | 5.01 |
| CHEMBL4740815 | — | — | 1 | - |
| CHEMBL4793857 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764237 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4780886 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4776850 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4530093 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4753981 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4798810 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4742088 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL333928 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4754467 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL4762281 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL4788921 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4742000 | — | IC50 | = | 1426.0 | nM | 5.85 |
| CHEMBL4760627 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4787700 | — | IC50 | = | 9840.0 | nM | 5.01 |
| CHEMBL4740815 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4793857 | — | IC50 | > | 40000.0 | nM | - |