Assay Detail
Binding
CHEMBL4703118
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Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.66 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747269 | — | — | 1 | 9.00 |
| CHEMBL4790231 | — | — | 1 | 8.85 |
| CHEMBL4763667 | — | — | 1 | 8.70 |
| CHEMBL4752248 | — | — | 1 | 8.54 |
| CHEMBL4740830 | — | — | 1 | 8.30 |
| CHEMBL4782307 | — | — | 1 | 8.22 |
| CHEMBL4751166 | — | — | 1 | 8.03 |
| CHEMBL4795827 | — | — | 1 | 7.82 |
| CHEMBL4755252 | — | — | 1 | 7.70 |
| CHEMBL4776151 | — | — | 1 | 7.55 |
| CHEMBL4800005 | — | — | 1 | 7.14 |
| CHEMBL4760380 | — | — | 1 | 7.14 |
| CHEMBL4753981 | — | — | 1 | 7.10 |
| CHEMBL4747086 | — | — | 1 | 7.03 |
| CHEMBL4763067 | — | — | 1 | 6.91 |
| CHEMBL4761170 | — | — | 1 | 6.85 |
| CHEMBL4792720 | — | — | 1 | 6.80 |
| CHEMBL4763260 | — | — | 1 | 6.21 |
| CHEMBL4783713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747269 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4790231 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4763667 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4752248 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4740830 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4782307 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4751166 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL4795827 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4755252 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4776151 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4800005 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4760380 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4753981 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4747086 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4763067 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4761170 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4792720 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL4763260 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL4783713 | — | IC50 | > | 1500.0 | nM | - |