Assay Detail
Binding
CHEMBL4703121
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Inhibition of TPO (unknown origin) using 3-iodo tyrosine as substrate incubated for 10 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.00 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753981 | — | — | 1 | 5.66 |
| CHEMBL4792720 | — | — | 1 | 5.20 |
| CHEMBL4755252 | — | — | 1 | 4.91 |
| CHEMBL4751166 | — | — | 1 | 4.23 |
| CHEMBL4800005 | — | — | 1 | - |
| CHEMBL4776151 | — | — | 1 | - |
| CHEMBL4782307 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4753981 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4792720 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4755252 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4751166 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL4800005 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4776151 | — | IC50 | > | 63000.0 | nM | - |
| CHEMBL4782307 | — | IC50 | > | 32000.0 | nM | - |