Assay Detail
Binding
CHEMBL4703347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal 6x-His tagged FGFR4 catalytic domain (445-753 residues) (unknown origin) using IYGEFKKK substrate and [gamma-32P]-ATP incubated for 30 mins by scintillation counting based paper disk assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Potent and Specific FGFR4 Inhibitor for the Treatment of Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.39 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744686 | — | — | 1 | 9.40 |
| CHEMBL4068896 | — | — | 1 | 8.94 |
| CHEMBL4757733 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744686 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4068896 | — | IC50 | = | 1.16 | nM | 8.94 |
| CHEMBL4757733 | — | IC50 | = | 145.0 | nM | 6.84 |