Assay Detail
ADMET
CHEMBL4703666
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluorimetric assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.08 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4212454 | — | — | 1 | 9.90 |
| CHEMBL4217414 | — | — | 1 | 9.30 |
| CHEMBL564131 | — | — | 1 | 8.90 |
| CHEMBL4752430 | — | — | 1 | 8.40 |
| CHEMBL4792408 | — | — | 1 | 8.30 |
| CHEMBL4776795 | — | — | 1 | 8.30 |
| CHEMBL4760625 | — | — | 1 | 8.30 |
| CHEMBL4792949 | — | — | 1 | 8.00 |
| CHEMBL4761511 | — | — | 1 | 7.90 |
| CHEMBL550246 | — | — | 1 | 7.70 |
| CHEMBL4442543 | — | — | 1 | 7.70 |
| CHEMBL4784502 | — | — | 1 | 7.60 |
| CHEMBL4741237 | — | — | 1 | 7.60 |
| CHEMBL4750552 | — | — | 1 | 7.50 |
| CHEMBL4763131 | — | — | 1 | 7.40 |
| CHEMBL4463665 | — | — | 1 | 7.30 |
| CHEMBL4764822 | — | — | 1 | 7.30 |
| CHEMBL4792937 | — | — | 1 | 7.20 |
| CHEMBL4799785 | — | — | 1 | 7.10 |
| CHEMBL344174 | — | — | 1 | 6.90 |
| CHEMBL371466 | — | — | 1 | 6.90 |
| CHEMBL4780035 | — | — | 1 | 6.60 |
| CHEMBL4741557 | — | — | 1 | 6.60 |
| CHEMBL4754825 | — | — | 1 | 6.30 |
| CHEMBL4740550 | — | — | 1 | 6.30 |
| CHEMBL4754896 | — | — | 1 | 6.20 |
| CHEMBL4751553 | — | — | 1 | 6.20 |
| CHEMBL4784967 | — | — | 1 | 6.00 |
| CHEMBL4745460 | — | — | 1 | 6.00 |
| CHEMBL4788271 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4212454 | — | Ki | = | 0.1259 | nM | 9.90 |
| CHEMBL4217414 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL564131 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL4752430 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL4792408 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL4776795 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL4760625 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL4792949 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4761511 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL4442543 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL550246 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL4784502 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL4741237 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL4750552 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL4763131 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL4463665 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL4764822 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL4792937 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL4799785 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL371466 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL344174 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL4780035 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL4741557 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL4754825 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4740550 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4754896 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL4751553 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL4784967 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4788271 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4745460 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL200374 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL4756127 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL200160 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL4789765 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL4741957 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL4751635 | — | Ki | = | 10000.0 | nM | 5.00 |