Assay Detail
Binding
CHEMBL4703796
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human partial length TRKA expressed in mammalian expression system by kinomescan method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.87 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4646064 | — | — | 1 | 9.09 |
| CHEMBL4790500 | — | — | 1 | 9.06 |
| CHEMBL4798635 | — | — | 1 | 9.00 |
| CHEMBL4742649 | — | — | 1 | 8.68 |
| CHEMBL4779847 | — | — | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4646064 | — | Kd | = | 0.81 | nM | 9.09 |
| CHEMBL4790500 | — | Kd | = | 0.88 | nM | 9.06 |
| CHEMBL4798635 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL4742649 | — | Kd | = | 2.1 | nM | 8.68 |
| CHEMBL4779847 | — | Kd | = | 2.9 | nM | 8.54 |