Assay Detail
Binding
CHEMBL4704271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity in human KARPAS-1106P cells incubated for 2 hrs by proteasome-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KARPAS-1106P |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships of Noncovalent Immunoproteasome β5i-Selective Dipeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.40 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4759896 | — | — | 1 | 7.82 |
| CHEMBL4763116 | — | — | 1 | 7.62 |
| CHEMBL4741140 | — | — | 1 | 7.55 |
| CHEMBL4758484 | — | — | 1 | 7.41 |
| CHEMBL4796570 | — | — | 1 | 7.28 |
| CHEMBL4799140 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4759896 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4763116 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4741140 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4758484 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4796570 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4799140 | — | IC50 | = | 197.0 | nM | 6.71 |