Assay Detail
Functional
CHEMBL4705239
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Agonist activity at MOR/DOR in wild-type C57BL6 mouse spinal cord membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 60 mins by scintillation counting assay
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Spinal cord |
| Subcellular | Cell membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 9.27 | 10.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4795492 | — | — | 2 | 10.50 |
| CHEMBL20226 | DELTORPHIN II | — | 2 | 8.75 |
| CHEMBL38874 | DAMGO | — | 2 | 8.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4795492 | — | EC50 | = | 0.03162 | nM | 10.50 |
| CHEMBL4795492 | — | EC50 | = | 0.0348 | nM | 10.46 |
| CHEMBL20226 | DELTORPHIN II | EC50 | = | 1.78 | nM | 8.75 |
| CHEMBL20226 | DELTORPHIN II | EC50 | = | 1.778 | nM | 8.75 |
| CHEMBL38874 | DAMGO | EC50 | = | 2.69 | nM | 8.57 |
| CHEMBL38874 | DAMGO | EC50 | = | 2.692 | nM | 8.57 |