Assay Detail
Binding
CHEMBL4705243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at EA-fragment beta-arrestin-tagged human DOR expressed in human U2OS cell membranes assessed as stimulation beta-arrestin recruitment after 60 mins by Pathhunter chemiluminescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.48 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20226 | DELTORPHIN II | — | 1 | 8.10 |
| CHEMBL4781906 | — | — | 1 | 6.29 |
| CHEMBL1612697 | — | — | 1 | 6.09 |
| CHEMBL4795492 | — | — | 1 | 6.02 |
| CHEMBL4788377 | — | — | 1 | 5.89 |
| CHEMBL38874 | DAMGO | — | 1 | - |
| CHEMBL4760974 | — | — | 1 | - |
| CHEMBL4758061 | — | — | 1 | - |
| CHEMBL4761310 | — | — | 1 | - |
| CHEMBL4776176 | — | — | 1 | - |
| CHEMBL4783765 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20226 | DELTORPHIN II | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4781906 | — | EC50 | = | 509.0 | nM | 6.29 |
| CHEMBL1612697 | — | EC50 | = | 812.0 | nM | 6.09 |
| CHEMBL4795492 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4788377 | — | EC50 | = | 1296.0 | nM | 5.89 |
| CHEMBL38874 | DAMGO | EC50 | - | — | - | |
| CHEMBL4760974 | — | EC50 | - | — | - | |
| CHEMBL4758061 | — | EC50 | - | — | - | |
| CHEMBL4761310 | — | EC50 | - | — | - | |
| CHEMBL4776176 | — | EC50 | - | — | - | |
| CHEMBL4783765 | — | EC50 | - | — | - |