Compound Detail
CHEMBL4788377
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Basic Information
| ChEMBL ID | CHEMBL4788377 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCDYQCMLIHCJPG-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
499.7
MW (Da)
5.15
ALogP
4
HBA
1
HBD
61.9
PSA (Ų)
0.42
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL233 | EC50 | 7.5 | 7.5 | 32.0 | 1 |
| Opioid receptors; mu & delta CHEMBL2095149 | EC50 | 7.06 | 6.25 | 87.0 | 2 |
| Delta-type opioid receptor CHEMBL236 | EC50 | 5.89 | 5.89 | 1296.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | EC50 | = | 32.0 | nM | 7.5 | Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in huma... | 33170687 |
| Opioid receptors; mu & delta | EC50 | = | 87.0 | nM | 7.06 | Agonist activity at EA-fragment beta-arrestin-tagged human MOR/DOR expressed in ... | 33170687 |
| Delta-type opioid receptor | EC50 | = | 1296.0 | nM | 5.89 | Agonist activity at EA-fragment beta-arrestin-tagged human DOR expressed in huma... | 33170687 |
| Opioid receptors; mu & delta | EC50 | = | 3662.0 | nM | 5.44 | Agonist activity at EA-fragment beta-arrestin-tagged human MOR/DOR expressed in ... | 33170687 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33170687 | 10.1021/acs.jmedchem.0c00901 | Opioid receptors; mu & delta | 4 |
| 33170687 | 10.1021/acs.jmedchem.0c00901 | Mu-type opioid receptor | 3 |
| 33170687 | 10.1021/acs.jmedchem.0c00901 | Delta-type opioid receptor | 3 |
Data from ChEMBL 36 via Core Engine