Assay Detail
Functional
CHEMBL4705549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV2 ROD infected in human CEM/0 cells assessed as inhibition of virus-induced syncytia cell formation measured after 4 to 5 days by microscopic analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM/0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.16 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4791857 | — | — | 1 | 7.00 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.66 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | -1.0 | 1 | 6.40 |
| CHEMBL4792961 | — | — | 1 | 6.22 |
| CHEMBL4754622 | — | — | 1 | 6.21 |
| CHEMBL4757045 | — | — | 1 | 6.11 |
| CHEMBL4751622 | — | — | 1 | 6.08 |
| CHEMBL4785596 | — | — | 1 | 5.96 |
| CHEMBL4790264 | — | — | 1 | 5.92 |
| CHEMBL4797903 | — | — | 1 | 5.06 |
| CHEMBL4779618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4791857 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL991 | STAVUDINE | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4792961 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4754622 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4757045 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4751622 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4785596 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4790264 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4797903 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4779618 | — | EC50 | > | 10000.0 | nM | - |