Assay Detail
Binding
CHEMBL4705573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of F protein D486N mutant in Respiratory syncytial virus A2 infected in HepG2 cells assessed as reduction in virus-induced cytopathic effect incubated for 4 days by XTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human respiratory syncytial virus A2 |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Fusion glycoprotein F0 (CHEMBL3856166) ↗| Type | SINGLE PROTEIN |
| Organism | Human respiratory syncytial virus A (strain A2) |
Publication
Discovery of a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins through the modulation of atropisomer interconversion properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.83 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4740044 | — | — | 1 | 9.15 |
| CHEMBL4750881 | — | — | 1 | 8.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4740044 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4750881 | — | EC50 | = | 3.1 | nM | 8.51 |