Assay Detail
Functional
CHEMBL4707174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HuH-7 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.98 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749655 | — | — | 1 | 6.32 |
| CHEMBL4785064 | — | — | 1 | 6.30 |
| CHEMBL4744689 | — | — | 1 | 6.19 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.76 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.71 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749655 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4785064 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4744689 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 2680.0 | nM | 5.57 |