Assay Detail
Binding
CHEMBL4707368
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Displacement of [3H]-prazosin from alpha1 adrenergic receptor in rat cortex measured after 30 mins by microbeta2 scintillation counting method
21
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT Receptor-Biased Agonists with Robust Antidepressant-like Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.93 | 7.63 |
| pKi | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4759629 | — | — | 1 | 7.63 |
| CHEMBL4740097 | — | — | 1 | 7.26 |
| CHEMBL4754941 | — | — | 1 | 6.89 |
| CHEMBL4753328 | — | — | 1 | 6.78 |
| CHEMBL4786537 | — | — | 1 | 6.75 |
| CHEMBL4741857 | — | — | 1 | 6.29 |
| CHEMBL4789505 | — | — | 1 | - |
| CHEMBL4793515 | — | — | 1 | - |
| CHEMBL4742112 | — | — | 1 | - |
| CHEMBL230963 | — | — | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | - |
| CHEMBL4742122 | — | — | 1 | - |
| CHEMBL4761382 | — | — | 1 | - |
| CHEMBL4753414 | — | — | 1 | - |
| CHEMBL4745099 | — | — | 1 | - |
| CHEMBL4777084 | — | — | 1 | - |
| CHEMBL4753988 | — | — | 1 | - |
| CHEMBL4748858 | — | — | 1 | - |
| CHEMBL4754363 | — | — | 1 | - |
| CHEMBL4746734 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4759629 | — | Ki | = | 23.44 | nM | 7.63 |
| CHEMBL4740097 | — | Ki | = | 54.95 | nM | 7.26 |
| CHEMBL4754941 | — | Ki | = | 128.82 | nM | 6.89 |
| CHEMBL4753328 | — | Ki | = | 165.96 | nM | 6.78 |
| CHEMBL4786537 | — | Ki | = | 177.83 | nM | 6.75 |
| CHEMBL4741857 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL4789505 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4793515 | — | pKi | - | — | - | |
| CHEMBL4742112 | — | pKi | - | — | - | |
| CHEMBL230963 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL56 | 8-OH-DPAT | pKi | - | — | - | |
| CHEMBL49 | BUSPIRONE | pKi | - | — | - | |
| CHEMBL4742122 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4761382 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4753414 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4745099 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4777084 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4753988 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4748858 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4754363 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4746734 | — | Ki | > | 1000.0 | nM | - |