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Assay Detail

CHEMBL4707903

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Functional
Cytotoxicity against human Hep3B cells assessed as growth inhibition measured after 72 hrs by MTT assay
ChEMBL ↗
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Hep 3B2
Confidence 1 — Organism
Curated By Autocuration

Target

Hep 3B2 (CHEMBL4296437) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin.
Yang,CJ.; Li,B.; Zhang,ZJ.; Gao,JM.; Wang,MJ.; Zhao,XB.; Song,ZL.; Liu,YQ.; Li,H.; Chen,Y.; Lee,KH.; Morris-Natschke,SL.; Xu,C.
Eur J Med Chem (2020) 187 : 111971 -111971
PubMed 31881457 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 47 7.77 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4793468 — — 1 9.22
CHEMBL4784440 — — 1 8.89
CHEMBL4789141 — — 1 8.82
CHEMBL4764303 — — 1 8.82
CHEMBL4777686 — — 1 8.72
CHEMBL4788934 — — 1 8.72
CHEMBL4740751 — — 1 8.68
CHEMBL4783889 — — 1 8.68
CHEMBL4742027 — — 1 8.64
CHEMBL4764642 — — 1 8.39
CHEMBL4782938 — — 1 8.38
CHEMBL4758216 — — 1 8.35
CHEMBL4794668 — — 1 8.28
CHEMBL4780383 — — 1 8.24
CHEMBL4796705 — — 1 8.17
CHEMBL4741735 — — 1 8.13
CHEMBL4756513 — — 1 8.11
CHEMBL84 TOPOTECAN 4.0 1 8.10
CHEMBL4797363 — — 1 7.96
CHEMBL4786760 — — 1 7.92
CHEMBL4794504 — — 1 7.91
CHEMBL4755881 — — 1 7.89
CHEMBL4764868 — — 1 7.88
CHEMBL4741783 — — 1 7.86
CHEMBL4744610 — — 1 7.75
CHEMBL4763180 — — 1 7.74
CHEMBL4787080 — — 1 7.67
CHEMBL4764604 — — 1 7.66
CHEMBL4756330 — — 1 7.58
CHEMBL4744197 — — 1 7.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4793468 — IC50 = 0.6 nM 9.22
CHEMBL4784440 — IC50 = 1.3 nM 8.89
CHEMBL4764303 — IC50 = 1.5 nM 8.82
CHEMBL4789141 — IC50 = 1.5 nM 8.82
CHEMBL4777686 — IC50 = 1.9 nM 8.72
CHEMBL4788934 — IC50 = 1.9 nM 8.72
CHEMBL4740751 — IC50 = 2.1 nM 8.68
CHEMBL4783889 — IC50 = 2.1 nM 8.68
CHEMBL4742027 — IC50 = 2.3 nM 8.64
CHEMBL4764642 — IC50 = 4.1 nM 8.39
CHEMBL4782938 — IC50 = 4.2 nM 8.38
CHEMBL4758216 — IC50 = 4.5 nM 8.35
CHEMBL4794668 — IC50 = 5.2 nM 8.28
CHEMBL4780383 — IC50 = 5.7 nM 8.24
CHEMBL4796705 — IC50 = 6.7 nM 8.17
CHEMBL4741735 — IC50 = 7.4 nM 8.13
CHEMBL4756513 — IC50 = 7.7 nM 8.11
CHEMBL84 TOPOTECAN IC50 = 7.9 nM 8.10
CHEMBL4797363 — IC50 = 11.1 nM 7.96
CHEMBL4786760 — IC50 = 11.9 nM 7.92
CHEMBL4794504 — IC50 = 12.2 nM 7.91
CHEMBL4755881 — IC50 = 13.0 nM 7.89
CHEMBL4764868 — IC50 = 13.3 nM 7.88
CHEMBL4741783 — IC50 = 13.7 nM 7.86
CHEMBL4744610 — IC50 = 17.8 nM 7.75
CHEMBL4763180 — IC50 = 18.4 nM 7.74
CHEMBL4787080 — IC50 = 21.4 nM 7.67
CHEMBL4764604 — IC50 = 22.0 nM 7.66
CHEMBL4756330 — IC50 = 26.4 nM 7.58
CHEMBL4744197 — IC50 = 45.3 nM 7.34
CHEMBL4752958 — IC50 = 51.7 nM 7.29
CHEMBL4761330 — IC50 = 51.5 nM 7.29
CHEMBL4764591 — IC50 = 52.9 nM 7.28
CHEMBL4752883 — IC50 = 58.6 nM 7.23
CHEMBL4788928 — IC50 = 78.6 nM 7.11
CHEMBL4743143 — IC50 = 79.1 nM 7.10
CHEMBL4754817 — IC50 = 89.7 nM 7.05
CHEMBL4760371 — IC50 = 96.4 nM 7.02
CHEMBL4779170 — IC50 = 105.6 nM 6.98
CHEMBL4742922 — IC50 = 115.9 nM 6.94
CHEMBL4741887 — IC50 = 136.8 nM 6.86
CHEMBL4754567 — IC50 = 148.7 nM 6.83
CHEMBL4784813 — IC50 = 176.0 nM 6.75
CHEMBL4780275 — IC50 = 343.0 nM 6.46
CHEMBL4750476 — IC50 = 513.0 nM 6.29
CHEMBL4785214 — IC50 = 602.5 nM 6.22
CHEMBL4787367 — IC50 > 1000.0 nM -