Assay Detail
Functional
CHEMBL4707906
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Cytotoxicity against human KB cells assessed as growth inhibition measured after 72 hrs by MTT assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 7.01 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4793468 | — | — | 1 | 8.08 |
| CHEMBL4750476 | — | — | 1 | 7.81 |
| CHEMBL4796705 | — | — | 1 | 7.76 |
| CHEMBL4754817 | — | — | 1 | 7.71 |
| CHEMBL4780383 | — | — | 1 | 7.63 |
| CHEMBL4742027 | — | — | 1 | 7.62 |
| CHEMBL4758216 | — | — | 1 | 7.38 |
| CHEMBL4740751 | — | — | 1 | 7.37 |
| CHEMBL4752958 | — | — | 1 | 7.29 |
| CHEMBL4741887 | — | — | 1 | 7.27 |
| CHEMBL4764642 | — | — | 1 | 7.23 |
| CHEMBL4794668 | — | — | 1 | 7.23 |
| CHEMBL4777686 | — | — | 1 | 7.22 |
| CHEMBL4761330 | — | — | 1 | 7.18 |
| CHEMBL4744610 | — | — | 1 | 7.17 |
| CHEMBL4742922 | — | — | 1 | 7.15 |
| CHEMBL4744197 | — | — | 1 | 7.15 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.14 |
| CHEMBL4783889 | — | — | 1 | 7.12 |
| CHEMBL4794504 | — | — | 1 | 7.12 |
| CHEMBL4788928 | — | — | 1 | 7.11 |
| CHEMBL4780275 | — | — | 1 | 7.10 |
| CHEMBL4755881 | — | — | 1 | 7.10 |
| CHEMBL4782938 | — | — | 1 | 7.09 |
| CHEMBL4754567 | — | — | 1 | 7.09 |
| CHEMBL4741735 | — | — | 1 | 7.08 |
| CHEMBL4779170 | — | — | 1 | 7.07 |
| CHEMBL4764868 | — | — | 1 | 7.06 |
| CHEMBL4741783 | — | — | 1 | 7.05 |
| CHEMBL4756513 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4793468 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4750476 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL4796705 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL4754817 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL4780383 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL4742027 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4758216 | — | IC50 | = | 41.4 | nM | 7.38 |
| CHEMBL4740751 | — | IC50 | = | 42.8 | nM | 7.37 |
| CHEMBL4752958 | — | IC50 | = | 51.1 | nM | 7.29 |
| CHEMBL4741887 | — | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL4764642 | — | IC50 | = | 58.6 | nM | 7.23 |
| CHEMBL4794668 | — | IC50 | = | 58.8 | nM | 7.23 |
| CHEMBL4777686 | — | IC50 | = | 60.4 | nM | 7.22 |
| CHEMBL4761330 | — | IC50 | = | 65.8 | nM | 7.18 |
| CHEMBL4744610 | — | IC50 | = | 67.6 | nM | 7.17 |
| CHEMBL4742922 | — | IC50 | = | 70.8 | nM | 7.15 |
| CHEMBL4744197 | — | IC50 | = | 70.2 | nM | 7.15 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 71.8 | nM | 7.14 |
| CHEMBL4783889 | — | IC50 | = | 76.4 | nM | 7.12 |
| CHEMBL4794504 | — | IC50 | = | 75.2 | nM | 7.12 |
| CHEMBL4788928 | — | IC50 | = | 78.6 | nM | 7.11 |
| CHEMBL4780275 | — | IC50 | = | 79.9 | nM | 7.10 |
| CHEMBL4755881 | — | IC50 | = | 80.1 | nM | 7.10 |
| CHEMBL4754567 | — | IC50 | = | 80.7 | nM | 7.09 |
| CHEMBL4782938 | — | IC50 | = | 81.3 | nM | 7.09 |
| CHEMBL4741735 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4779170 | — | IC50 | = | 84.6 | nM | 7.07 |
| CHEMBL4764868 | — | IC50 | = | 87.7 | nM | 7.06 |
| CHEMBL4741783 | — | IC50 | = | 88.8 | nM | 7.05 |
| CHEMBL4756513 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4786760 | — | IC50 | = | 89.2 | nM | 7.05 |
| CHEMBL4787367 | — | IC50 | = | 90.6 | nM | 7.04 |
| CHEMBL4752883 | — | IC50 | = | 91.5 | nM | 7.04 |
| CHEMBL4784440 | — | IC50 | = | 94.6 | nM | 7.02 |
| CHEMBL4787080 | — | IC50 | = | 104.2 | nM | 6.98 |
| CHEMBL4763180 | — | IC50 | = | 115.3 | nM | 6.94 |
| CHEMBL4764303 | — | IC50 | = | 139.6 | nM | 6.86 |
| CHEMBL4764591 | — | IC50 | = | 293.1 | nM | 6.53 |
| CHEMBL4789141 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL4797363 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL4756330 | — | IC50 | = | 388.5 | nM | 6.41 |
| CHEMBL4764604 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL4788934 | — | IC50 | = | 560.3 | nM | 6.25 |
| CHEMBL4785214 | — | IC50 | = | 753.2 | nM | 6.12 |
| CHEMBL4784813 | — | IC50 | = | 775.5 | nM | 6.11 |
| CHEMBL4743143 | — | IC50 | = | 894.3 | nM | 6.05 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 6314.3 | nM | 5.20 |
| CHEMBL4760371 | — | IC50 | > | 1000.0 | nM | - |