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Assay Detail

CHEMBL4707907

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Functional
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition measured after 72 hrs by MTT assay
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin.
Yang,CJ.; Li,B.; Zhang,ZJ.; Gao,JM.; Wang,MJ.; Zhao,XB.; Song,ZL.; Liu,YQ.; Li,H.; Chen,Y.; Lee,KH.; Morris-Natschke,SL.; Xu,C.
Eur J Med Chem (2020) 187 : 111971 -111971
PubMed 31881457 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 48 6.40 7.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4796705 — — 1 7.02
CHEMBL4742027 — — 1 7.02
CHEMBL84 TOPOTECAN 4.0 1 6.99
CHEMBL4793468 — — 1 6.90
CHEMBL4750476 — — 1 6.86
CHEMBL4758216 — — 1 6.83
CHEMBL4754817 — — 1 6.74
CHEMBL4744610 — — 1 6.70
CHEMBL4780383 — — 1 6.70
CHEMBL4764642 — — 1 6.69
CHEMBL4752958 — — 1 6.67
CHEMBL4741887 — — 1 6.66
CHEMBL4794668 — — 1 6.54
CHEMBL4794504 — — 1 6.50
CHEMBL4777686 — — 1 6.48
CHEMBL4784440 — — 1 6.47
CHEMBL4786760 — — 1 6.47
CHEMBL4789141 — — 1 6.42
CHEMBL4740751 — — 1 6.42
CHEMBL4744197 — — 1 6.41
CHEMBL4764868 — — 1 6.40
CHEMBL4754567 — — 1 6.37
CHEMBL4782938 — — 1 6.36
CHEMBL4764303 — — 1 6.35
CHEMBL4797363 — — 1 6.33
CHEMBL4742922 — — 1 6.30
CHEMBL4787080 — — 1 6.29
CHEMBL4761330 — — 1 6.26
CHEMBL4741735 — — 1 6.25
CHEMBL4788928 — — 1 6.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4796705 — IC50 = 95.1 nM 7.02
CHEMBL4742027 — IC50 = 96.3 nM 7.02
CHEMBL84 TOPOTECAN IC50 = 101.5 nM 6.99
CHEMBL4793468 — IC50 = 125.6 nM 6.90
CHEMBL4750476 — IC50 = 138.5 nM 6.86
CHEMBL4758216 — IC50 = 148.5 nM 6.83
CHEMBL4754817 — IC50 = 183.7 nM 6.74
CHEMBL4744610 — IC50 = 201.5 nM 6.70
CHEMBL4780383 — IC50 = 200.4 nM 6.70
CHEMBL4764642 — IC50 = 202.1 nM 6.69
CHEMBL4752958 — IC50 = 216.1 nM 6.67
CHEMBL4741887 — IC50 = 217.6 nM 6.66
CHEMBL4794668 — IC50 = 289.4 nM 6.54
CHEMBL4794504 — IC50 = 312.9 nM 6.50
CHEMBL4777686 — IC50 = 330.0 nM 6.48
CHEMBL4784440 — IC50 = 337.8 nM 6.47
CHEMBL4786760 — IC50 = 334.8 nM 6.47
CHEMBL4789141 — IC50 = 383.7 nM 6.42
CHEMBL4740751 — IC50 = 379.7 nM 6.42
CHEMBL4744197 — IC50 = 388.0 nM 6.41
CHEMBL4764868 — IC50 = 396.1 nM 6.40
CHEMBL4754567 — IC50 = 427.5 nM 6.37
CHEMBL4782938 — IC50 = 433.2 nM 6.36
CHEMBL4764303 — IC50 = 445.9 nM 6.35
CHEMBL4797363 — IC50 = 468.9 nM 6.33
CHEMBL4742922 — IC50 = 495.1 nM 6.30
CHEMBL4787080 — IC50 = 507.4 nM 6.29
CHEMBL4761330 — IC50 = 547.7 nM 6.26
CHEMBL4741735 — IC50 = 564.4 nM 6.25
CHEMBL4788928 — IC50 = 560.0 nM 6.25
CHEMBL4780275 — IC50 = 624.3 nM 6.21
CHEMBL4755881 — IC50 = 625.9 nM 6.20
CHEMBL4787367 — IC50 = 648.6 nM 6.19
CHEMBL4741783 — IC50 = 645.6 nM 6.19
CHEMBL4756513 — IC50 = 689.4 nM 6.16
CHEMBL4764591 — IC50 = 685.7 nM 6.16
CHEMBL4763180 — IC50 = 708.1 nM 6.15
CHEMBL4779170 — IC50 = 743.1 nM 6.13
CHEMBL4756330 — IC50 = 758.9 nM 6.12
CHEMBL4752883 — IC50 = 807.6 nM 6.09
CHEMBL4783889 — IC50 = 874.6 nM 6.06
CHEMBL4788934 — IC50 = 961.4 nM 6.02
CHEMBL481 IRINOTECAN IC50 = 14282.0 nM 4.84
CHEMBL4743143 — IC50 > 1000.0 nM -
CHEMBL4764604 — IC50 > 1000.0 nM -
CHEMBL4784813 — IC50 > 1000.0 nM -
CHEMBL4785214 — IC50 > 1000.0 nM -
CHEMBL4760371 — IC50 > 1000.0 nM -